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In this trial, 30 mg per day of pioglitazone was associated with less loss of muscle mass measured by computed tomography (CT) and DXA over the 16 week follow-up [127], although the difference compared with the control group did not reach statistical significance

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More precisely, we investigated whether effects were driven by either an increase in parasympathetic nervous system (PNS) activity or a decrease in sympathetic nervous system (SNS) activity, as both can lead to enhanced insulin secretion 21 (Supplementary Fig