IGF-1 level, SHIM, and EPIC scores were 235.086.4, 19.58.7 and 56.428.3 mg ml1, respectively
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Prespecified subgroup, sensitivity and specificity analyses Subgroup analyses were conducted based on gender, age, body mass index (BMI), HbA1c, DM status (pre-existing or post-transplant), post-transplant eGFR, the presence of hypertension, proteinuria, heart failure, obesity, enrollment time, prior history of GLP-1RAs uses before transplant, and the concurrent use of medications, including ACEIs/ARBs, antidiabetic agents (insulin, metformin, dipeptidyl peptidase-4 inhibitors (DPP-4is), sodium-glucose cotransporter 2 inhibitors (SGLT2is), and immunosuppressants (steroids, cyclosporine and tacrolimus)
Estrogens play a key role in the regulation of multiple physiological processes, such as sexual development, the stress response, tissue differentiation and the regulation of energy metabolism
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In other cells, it is maintained in its reduced form by reaction with glutathione [17]