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Of additional interest and based on a proteomic analysis of the plasma from 240 healthy, disease-free, humans in the age range 22-93 years-old, GDF15 was identified as the protein most positively correlated with chronological age and also known to reduce appetite via an action in the hind-brain (82, 95)

Yoo M, Cho S, Shin S, Kim JM, Park HG, Cho S, Hwang YK, Park DH

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Berberine repairs intestinal permeability, stabilizes blood sugar, and neutralizes the bacterial toxin LPS ( 22 )

Cell Stem Cell 13, 270283