This process protects tissues from chemical damage while maintaining cellular stability
59 HamzaI.GitlinJ
A well-established mechanism by which AGEs promote oxidative stress involves binding to the receptor for AGEs (RAGE) and activation of intracellular signaling cascades including MAPK and NF-B, which upregulate pro-oxidant pathways such as NADPH oxidase and increase reactive oxygen species (ROS) generation 43,44,45,46
Finally, as the presented evidence shows, controlling/modulating angiogenesis [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40] should occur along with similar corresponding controlling/modulating of NO-system functioning [11,29,92,93,94,97,98,99] (see below, Section 3)
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Zinc maintains this process, reducing the chances of blocked pores