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Based on data in 2017, the global average incidence rate is 9.1%, with about 700 million patients registered [2] and, in the following 10 years, CKD will swiftly become the fifth leading cause of mortality globally [3]

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In chemotherapy-induced pyroptosis, gasdermin E ( GSDME) is palmitoylated at Cys407 and Cys408 within its C-terminal domain

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Disease evolution and response to rapamycin in activated phosphoinositide 3-kinase delta syndrome: the european society for immunodeficiencies-activated phosphoinositide 3-kinase delta syndrome registry