2004 Jul;40(1):6-9
However, there are also some host factors, such as polymorphism of the IL-1, which influences gastric acid secretion, or polymorphism of the CYP2C19, which is the main enzyme metabolizing PPI (proton pump inhibitor), that are associated with the risk of gastric cancer development (Uotani et al
For instance, white adipose tissue from obese women showed to have a lower expression of total GHR mRNA compared with those from lean women, and the expression of GHR mRNA was also found to be higher in visceral white adipose tissue than in subcutaneous white adipose tissue in the lean women group (204)
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Some investigators have suggested that the uremia of CKD is associated with decreased GH signalling contributing to the state of hepatic GH resistance (74) ( Figure 4 )