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Relative to systemic synthetic hormones, many peptides have shorter half-lives and more targeted action, which can alleviate systemic side effects and necessitate accurate dosing

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The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling