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It is plausible that the lack of ergogenic effects could be attributed to the trained participant cohort in the cycling studies (VO 2peak range = 56.3 58.1 ml.kg 1 .min 1 ), such that a recent point-counterpoint debate suggests due to an elevated NO at baseline compared to their untrained counterparts this could blunt the ergogenic effect (Hultstrm et al

H., Lai, M

Medicine (Baltimore) 2021;100(6):e24590

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer