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This is not a minor concern or a technicality

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the reduced melanocyte differentiation gene expression has its counterpart at the tissue level by virtue of absent expression of melanocyte lineage-specific markers such as HMB-45 and Melan-A, 6 tyrosinase and D5, an antibody to microphthalmia transcription factor (Mit-f)

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In our experiment, some indicators in the blood gas analysis of the plateau animal model changed when the simulated altitude was 6000 m