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More research needs to be done, but this effect may be due to GLP-1s ability to reduce inflammation or aid in sodium processing, which can result in lowered blood pressure, a marker of metabolic health

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Elutions were pooled, and the GST tag was removed from FAT via Thrombin Cleavage Kit (Sigma) into 50 mM Tris pH 8.0, 200 mM CaCl 2

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In the intracellular domain, the sharp kink around the conserved Pro 6.47b -X-X-Gly 6.50b motif in TM6 pivoted the intracellular half of TM6 to move outwards by 18.4 (measured by C carbon of K346 6.35b ), to the same extent as that achieved by orthosteric agonists (Supplementary Fig