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Additionally, we noted the inhibition of cell death with Nec-1, suggesting that OGD has the potential to induce necroptosis, aligning with findings by Qi et al

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Funding This work was supported by NIAAA intramural research program (Grant Y1AA3009)

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Its primary biological functions center on tissue remodeling: it stimulates collagen synthesis (types I and III), promotes decorin production, increases glycosaminoglycan synthesis, and activates metalloproteinase pathways for controlled tissue remodeling