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J Biomed Sci (2017) 24(1):76

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Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the krasg12d mouse model

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doi: 10.1111/1753-0407.12891 Summary Keywords diabetic kidney disease, diabetic nephropathy, GLP-1 receptor agonists, liraglutide, semaglutide, dulaglutide Citation Kawanami D and Takashi Y (2020) GLP-1 Receptor Agonists in Diabetic Kidney Disease: From Clinical Outcomes to Mechanisms

[56] Semaglutide counteracts this resistance by downregulating inhibitory proteins like SOCS3 and PTP1B