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The Evidence: NR Is Backed by Significantly More Research Than Oral NAD+ While NAD+ itself is well-understood biologically, there is surprisingly little data on the effects of oral NAD+ supplementation in humans

Consequences of the -ketoglutarate dehydrogenase inhibition for neuronal metabolism and survival: implications for neurodegenerative diseases

So, is there a concern about overdose

V., Roberts, B., Gudi, V

According to a recent study on The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 (1) glutathione levels in the body were directly linked to the severity of the inflammatory response in COVID-19 patients, with the most-severe responses among those with severely depleted levels irrespective of comorbidities (2,1)

Teperino, R