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This improvement occurs because increased collagen production helps fill in fine lines and wrinkles from within the skin layers, rather than just temporarily plumping the surface

8.5 Extension to dual, triple-agonist and amylin-based co-agonist therapies The emergence of dual and multi-agonist therapies, such as the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist tirzepatide, raises important questions regarding the generalisability of the proposed framework

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View Study [3]"Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity" Garvey WT et al., 2025 Finding: The REDEFINE 1 Phase 3 trial showed CagriSema achieved 20.4% weight loss versus 3% with placebo over 68 weeks in 3,417 participants