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The second group are patients with extreme symptoms or who for some reason cannot wait for physical therapy to become effective

10.1007/978-3-031-69188-1_7 239 TangM.ZengY.PengW.XieX.YangY.JiB.et al (2023)

Most people take GLP-1 medications long-term to maintain weight loss

doi:10.4093/dmj.2025.0242 3

This approach exploits the positioning of USP14 in the RP, and shares similarities with the recently described Rpn1-directed chimeras 34 , although in that case the Rpn1 ligands were based on macrocyclic peptides