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All the drugs were prepared by dissolving in ddH 2 O and sterilized before use

The efficacy of the checkpoint inhibitor immunotherapy is augmented in the presence of Bifidobacterium and Bacillus fragilis through the shaping of the host immune system (145, 146)

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Additionally, patients with specific medical conditionssuch as kidney disease, liver disease, or particular blood disorderswill require careful monitoring and possibly dosage adjustments by our clinical team, as excessive vitamin B12 supplementation could lead to complications