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These may include diabetes, metabolic syndrome, or thyroid disease

Diabetes Obes Metab 17:11801193 Irace C, Casciaro F, Scavelli FB, Oliverio R, Cutruzzol A, Cortese C, Gnasso A (2018) Empagliflozin influences blood viscosity and wall shear stress in subjects with type 2 diabetes mellitus compared with incretin-based therapy

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26 Quantitative analysis has revealed a progressive increase in placenta-derived EV concentration across gestation, with GDM patients showing consistently higher levels than healthy controls in each trimester

Somatostatin (growth hormone inhibiting hormone) decreases during sleep stages, removing inhibitory brake on growth hormone secretion