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Limited Penetration: As a hydrophilic molecule, ascorbic acid struggles to penetrate the skins lipid-rich barrier, limiting its ability to reach deeper layers where it can deliver benefits

Trends Pharmacol Sci (2017) 38:7634

This leads to outcomes that are difficult to sustain over time

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For example for VLCAD deficiency, the ratio of tetradecenoylcarnitine (C14:1) over acetylcarnitine (C2) resulted in less false-negative results when compared to C14:1 as the only marker [46, 57]

Diabetes diabetic peripheral neuropathy and metabolic changes both raise the risk