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Lixisenatide The maximum recommended dose of lixisenatide (Lyxumia) is 20 mcg once daily via subcutaneous injection and is licensed for use in people with T2D as monotherapy in those who cannot take metformin or as an add-on treatment to oral agents and/or insulin [31]

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An initial 50% dose reduction of a sulphonylurea is suggested for most patients, based on our collective clinical experience, depending on baseline HbA 1c

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