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The open question is whether microdosing produces enough of that effect to create meaningful clinical change

Semaglutide significantly downregulates the expression levels of key pro-inflammatory factors such as TNF-, IL-6, and IL-1 in the gastrocnemius muscle, while effectively improving IR, as evidenced by a significant reduction in the Homeostatic Model Assessment of Insulin Resistance index [28]

10.1016/j.alcohol.2010.06.006 304 WalkerN.Lepee-LorgeouxI.FournierJ.BetancurC.RosteneW.FerraraP.et al

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This is even more prevalent during menopause when maintaining muscle mass becomes more difficult (Nagy et al., 2025)

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