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IL-1 also promotes the release of danger signals such as HMGB1 from damaged cells, further amplifying the inflammatory response via the TLR4 pathway (discussed later in the mechanism of HMGB1) (Phan et al., 2022

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Larazotide is studied as a zonulin antagonist / tight-junction regulator : in mechanistic work it is associated with promoting the reassembly of tight-junction proteins and the underlying actin cytoskeleton, blunting the gliadin- and zonulin-induced rise in permeability [4] [5]

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India, the United States, and China report the highest disease burdens, with India alone accounting for approximately 20 million cases [9]