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This "hypothalamic-centric" regulatory model provides a new paradigm for obesity treatment one that does not rely on peripheral hormone systems but instead breaks through traditional targets to directly intervene in the central nervous system's perception of energy requirements

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Nyberg M, Mortensen SP, Cabo H, Gomez-Cabrera MC, Via J, Hellsten Y