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Sierra-Filardi E, Vega MA, Snchez-Mateos P, Corb AL, Puig-Krger A (2010) Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release

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This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months

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In clinical trials, several SGLT2i agents have been shown to reduce eGFR and albuminuria significantly (147)