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Safety Profile Summary A formal preclinical safety evaluation published in 2020 by Xu et al

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But these studies have important limitations: They rely on voluntary patient reports, not systematically collected data They cannot prove cause and effect Theyre considered less reliable than large randomized trials or carefully designed observational studies Because of that: The medical community is aware of this possible signal More research is ongoing For now, this is treated as something to monitor, not a proven risk If you have a personal or family history of pancreatic or thyroid cancer, thats something to discuss directly with your doctor before starting a GLP-1 drug