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Combining these agents poses unpredictable risks to glucose metabolism, as tesamorelin raises GH and can induce insulin resistance, potentially opposing retatrutide's glycaemic effects

For those with obesity complicated by diabetes, cardiovascular disease, or metabolic syndrome, long-term or indefinite GLP-1 therapy is evidence-based and appropriate

A healthy gut can handle the slower emptying better

Scientific literature increasingly frames unimolecular multi-receptor agonism as the primary route toward bariatric-like weight loss outcomes, combining appetite reduction with enhanced energy expenditure and broader metabolic effects [1, 2, 3]

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