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An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., However, a further examination of this hypothesis, for example using the topology of the metabolic network in Figure 1, shows there might be difficulties with this interpretation

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It has been reported that RSS exhibit not only high nucleophilicity but also strong antioxidant activity and oxidative stress resistance compared with ordinary thiol compounds such as glutathione and cysteine

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