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Constipation and GLP-1 Medications: What You Need to Know Before Symptoms Start Constipation is a common but often overlooked side effect in people taking GLP-1 receptor agonists, a class of medications widely used to treat obesity and type 2 diabetes

The mechanism underlying these effects relates to individual tolerance and potential osmotic effects in some consumers

Avoid compounded semaglutide unless your doctor advises otherwise

In practice, that means a higher risk of severe nausea, vomiting, and GI distress than you had when starting either drug on its own

The insurer had spent over $300 million on GLP-1 medications, with projections showing costs approaching $1 billion by 2026 if trends continued

But they require close medical monitoring and a willingness to manage cost and side effects