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Clinicians should closely observe patients during treatment initiation and each titration step , documenting changes in weight, hydration status, gastrointestinal tolerance, and visual symptoms

The study, which was previewed in an August press release by the drugs maker and trial-runner Novo Nordisk, was published in full Saturday in the New England Journal of Medicine, timed to a presentation of the findings at the American Heart Association conference in Philadelphia

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These serve as messengers to the body and instruct the cells to carry out specific actions such as repairing tissue, synthesizing collagen, or triggering growth

Farxiga is approved to reduce the risk of hospitalization for heart failure in adults with T2DM and known heart disease or multiple cardiovascular risk factors (high blood pressure, high cholesterol, or obesity)