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While the share of ESI enrollees with a GLP-1 drug claim has been increasing, still only a relatively modest number of people have a claim Since 2012, the share of non-elderly adults with ESI that have a GLP-1 drug claim has grown more than eightfold (717.7% increase)

The global GLP-1 receptor agonist market size is valued at USD 53.5 billion in 2024 and is expected to grow to USD 62.86 billion by 2025

A 1 mg starting dose would be 40 units

Extended Data Figure 2 GLP-1R interhelical interaction network

That triple agonism is generating intense interest in pre-clinical metabolic-research circles, where investigators are comparing it head-to-head against the dual agonist Tirzepatide and the GLP-1 mono-agonist Semaglutide

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