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The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary

doi: 10.1101/gad.991402 138 Le GallL.AnakorE.ConnollyO.VijayakumarU.DuddyW.DuguezS

For deeper pigmentation concerns, dermatologists often combine glutathione with laser or peel treatments for stronger results

57,58 These patients had an increased concentration of the GSH degradative enzyme gamma-glutamyltranspeptidase in the SN, and a normal concentration of the synthetic enzyme gamma-glutamyl-cysteine synthetase

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