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SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials
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Some suppliers include desiccant packets, which help maintain dryness
Peripherally administered amylin inhibits stress-like behaviors and enhances cognitive performance