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A 28.3% reduction in body weight averaging 70.3 pounds lost over 80 weeks is the headline number from retatrutides TRIUMPH-1 phase 3 trial, and it lands at a moment when the obesity pharmacology field thought it had already seen its ceiling
7 However, future market development will depend on the patient journey, and which approaches payers are willing to reimburse first
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This stepwise escalation principle mirrors the approach used for licensed medicines such as semaglutide (Wegovy, UK SmPC available via the electronic Medicines Compendium) and tirzepatide (Mounjaro, UK SmPC available via the electronic Medicines Compendium), both of which are approved by the MHRA and recommended within relevant NICE guidance for specific indications
Early trial data suggest retatrutide could lead to greater average weight loss than tirzepatide, but its long-term safety, side effects, and real-world tolerability are still being studied
