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If you are also not losing weight on tirzepatide as expected, adequate hydration is one factor worth examining since dehydration can slow metabolism and impair fat oxidation

"In a first-of-its-kind trial, tirzepatide reduced severity of symptoms and improved heart failure outcomes in people with HFpEF and obesity." It's not clear how GLP-1 drugs exert their beneficial effects in cardiovascular diseases, but studies have suggested that it could be more than just a consequence of weight loss or a reduction in fat around the heart in the case of heart failure patients

Administration : Swallow with up to 120 mL (4 oz) plain water on an empty stomach in the morning

Prediction of cardiac autonomic neuropathy using a machine learning model in patients with diabetes

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GLP-1 medications, such as Ozempic, Wegovy, Mounjaro, and Zepbound are now prescribed commonly for people diagnosed with Type 2 diabetes and/or obesity