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doi: 10.1016/S0140-6736(19)31150-X 135 HonigbergMCChangLSMcGuireDKPlutzkyJArodaVRVaduganathanM

When a patient enters a significant caloric deficit, the body must catabolize (break down) stored energy

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Tachyphylaxis is contingent upon a full 24-hour exposure, as evidenced by a study in which rats treated with liraglutide (with half-life of 11 15 hours) twice daily for 14 days had markedly diminished gastric emptying while those treated with exenatide (with half-life of 2 3 hours) twice daily over the same period still displayed a profound reduction in gastric emptying, although both compounds had similar effects on body weight reduction (158)

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