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Nitric oxide modulation: It is often discussed in relation to nitric oxide signaling, which can influence circulation and endothelial function

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Activated microglia release IL-6, CCL5, and TNF- contributing to the activation and infiltration of mast cells [258]

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Other rare symptoms may include irritability, microcephaly, autism spectrum disorder, tremor, global developmental delay, coma, polyneuropathy, axial hypotonia, and daytime sleepiness [100, 102,103,104,105,106,107,108]