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In certain embodiments, from about a 5 mM to about a 200 mM concentration of a buffer is present

It was found that the OPFRs only increased the level of ROS and methemoglobin at very high concentrations: at 500 g/mL, they were found to induce morphological changes and ultimately cause lytic cell death and PS externalization

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Biotechnol Adv 36:358370 Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The coq oxidoreductase fsp1 acts parallel to gpx4 to inhibit ferroptosis

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