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Abstract Rational assembly of small molecule libraries for purposes of drug discovery requires an efficient approach in which the synthesis of bioactive compounds is enabled so that numerous structurally related compounds of a similar basic formulation can be derived

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TGF-1/Smad Pathway Inhibition in Hepatic Stellate Cells TGF-1 drives HSC fibrogenic activation through canonical Smad2/3 phosphorylation (ALK4/5Smad2-Ser423/425

These acylcarnitines can be exported from the mitochondria and cell, preventing the toxic accumulation of acyl-CoA intermediates that inhibit key metabolic enzymes