retatrutide and tirzepatide vs Tirzepatide: 28.7% vs 22.5% (2026) Retatrutide effects greatest Weight Loss

Kelly, T., et al

Travellers should check the storage instructions provided with their specific medication

Together, these metabolic and vascular effects of GLP-1 serve to form the basis for the therapeutic potential of GLP-1 RAs in cardiovascular conditions

Scientific References TripleHormone-Receptor Agonist Retatrutide for Obesity Phase 2 Trial

These typically peak when you start treatment or youre stepping up your doses (titration) and improve as your body adjusts: Because Retatrutide also targets glucagon, this alters how it affects your body, resulting in a couple of side effects not usually seen with Zepbound: 1

In addition, you will still have a membership fee which covers use of our app, chat features with your Shapely team, access to exclusive education, tracking tools, and concierge support locating medications at local pharmacies