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SMAD7 functions as an inhibitory SMAD that competes with R-SMADs for receptor binding, thereby negatively regulating the pathway [40]

It belongs to a class of drugs known as incretin-based therapies and is currently FDA-approved only as an injectable medication

In general, exercise may increase the level of Lac-Phe to alleviate atherosclerosis (Figure 3)

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9 When appetite is lower and food intake decreases, the nutritional quality of meals becomes more important