NSAIDs should be used cautiously in patients with renal impairment, cardiovascular disease, or gastrointestinal risk factors
SIRT1, the most studied sirtuin, directly influences how your body processes and stores fat
Once-monthly maridebart cafraglutide for the treatment of obesity - a phase 2 trial
Tirzepatide reduced body weight by 16%, 21.4%, and 22.5% on 5 mg, 10 mg, and 15 mg (once weekly injections), respectively, after 72 weeks
No new safety signals were identified, and no hypoglycemia was reported
We dont put a limit in terms of minimum clinically relevant effect size for PFS, as this depends on the balance with the risks. Tafuri adds: It may be time for the oncology community and regulatory agencies to take a hard look at PFS and reflect on whether this can be used as a primary efficacy endpoint in a specific oncology setting. It may be time to take a hard look at whether PFS can be used as a primary efficacy endpoint in a specific setting As Hartmann says, this can also be seen as part of a move to incorporate patient groups much more in evaluating what factors are important in the benefitrisk assessment of drugs