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Worse than this, some people gain weight when they take it

This is mediated by the ARC, PVH, and LH hypothalamic nuclei (188, 236)

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Woo I, Christenson LK, Gunewardena S, Ingles SA, Thomas S, Ahmady A, et al

As observed previously 13 , the putative flavan-3,3,4-triol ( 4 ) was not stable during purification, and confirmatory time-course experiments showed almost complete degradation of the intermediate ( 4 ) within 24 h (Extended Data Fig