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Overall Older Appearance: Collectively, these changes can make the face look older or more tired, resembling the effects of natural ageing

1% of patients receiving placebo

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Functional annotation using RegulomeDB v2 48 revealed the previously unidentified variant rs77247401 with moderate likelihood to be regulatory (rank = 4, score = 0.609), and the variant rs56159231 with high likelihood to be a functional variant (rank=1 f, score=0.554)

1016 Dewidar, B