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Dose optimization may be appropriate if you have not reached the maximum tolerated dose according to FDA labeling (up to 15 mg weekly)

Pinch the skin at the injection site to create a fold

doi: 10.1124/jpet.103.051987 89 DeYoungMBMacConellLSarinVTrautmannMHerbertP

It is a chronic relapsing disease that deserves modern medical treatment

[DOI] [PubMed] [Google Scholar] Bulgarian National Center ofPublic Health Protection (NCPHP) 2006

Because tirzepatide already stimulates both GLP-1 and GIP pathways, adding a GLP-1only agent (semaglutide) would create redundancy on the GLP-1 receptor without activating any new biological target