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Furthermore, the activity levels of antioxidant enzymes were significantly reduced in PV patients, although there were no differences in GSH-Px levels [101]
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Based on the fitted pKa of 6.87, which is in good agreement with the average of 6.52 from other reported values (11, 5759), the amount of niclosamide in aqueous solution increases in the higher pH range (of 8-9.5)
Elle exerce galement une inhibition directe de la tyrosinase par chlation des ions cuivre du site actif de lenzyme, amplifiant leffet dpigmentant
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