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Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
Journal of Cosmetic Dermatology.
Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors
101, 2031 10.1016/j.freeradbiomed.2016.09.020 [DOI] [PMC free article] [PubMed] [Google Scholar] 65.Benchoam D., Cuevasanta E., Mller M.N
Even after approval, manufacturing ramp-up and commercial launch logistics mean CagriSema likely will not be widely available to patients until the following year
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