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This process can be activated by cellular changes, including DNA damage, mitochondrial damage, withdrawal of growth factors and estrogen signaling [17, 37]

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Therefore, BIRD domain inactivation or deletion could constitutively activate transcription of purine pathway genes and synthesize an excess of GTP, which must be detoxified via riboflavin overproduction

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d-i , Autochthonous tumors from MMTV-PyMT Gclc f/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into the mammary gland or subcutaneously transplanted into the flank of wild-type C57BL/6 mice, which were treated with vehicle (corn oil