Nevertheless, we found a reduction in the expression of fatty acid transport proteins (e.g., CD36) and -oxidation key rate-limiting enzymes (e.g., ACOX1) upon pressure overload, which caused a reduction in fat oxidation and fatty acid accumulation (Fig
doi: 10.1073/pnas.0506982103, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 224
The FDA-approved titration protocol for prescription semaglutide (Ozempic, Wegovy) follows a specific progression: 0.25 mg weekly for 4 weeks, then 0.5 mg weekly, advancing to 1 mg, then 1.7 mg, and finally 2.4 mg depending on your response and tolerance
If this proves correct, blood-brain barrier penetrance may be the wrong language for a real but poorly understood phenomenon, and compound design should target whatever route actually delivers these peptides to the relevant neurons
I do my own
Science 362 , eaav4809 (2018)