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Brains of ASD patients also had high cytokine levels, including IL-6 and the Th1 cytokine IFN-, whereas levels of Th2 cytokines (i.e., IL-4, IL-5, and IL-10) were not elevated in brains in ASD patients (170)

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If the pain is purely centralized, therapies primarily focus on retraining the brain's pain pathways or using medications that alter central neurotransmitters