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Horm Metab Res (2018) 50:90821

The authors compile data showing GHK-Cu modulates expression of more than 4,000 human genes including substantial upregulation of antioxidant defense genes, DNA repair genes, and genes encoding collagen and elastin biosynthesis enzymes while downregulating pro-inflammatory and tissue-degradation pathways

However, the same clinical trial revealed that only 6.2% of patients maintained any benefit at 6 months post-treatment compared to 0% in the placebo group

Use the tube cream on areas needing richer moisture or where skin is rough/dry (knees, elbows, maybe face if compatible)

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With GLP-1 agonists, appetite typically returns to pre-treatment levels, and weight regain is common without lifestyle changes