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It was found that Nrf2 mediates cytoprotective genes expression through antioxidant responsive elements (ARE) until Nrf2-deficient mice were established and analyzed the stimulation of phase II detoxifying enzymes ( Kelch-like ECH-associated protein 1 (Keap1) was originally isolated by Itoh et al

When the blood vessels cannot properly regulate their tone due to a lack of nitric oxide and structural damage, blood pools in the lower extremities upon standing